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identifier: SDY299
description:
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
aggregation:
instance of dataset
availability:
available with registration
acknowledges:
NIAID (HIPC funded)
isAbout:
Document the changes in cellular responses and gene expression patterns in serial blood samples collected from healthy older adults after vaccination with HEPLISAV. Determine which of these changes correlate with the development of protective levels of antibody (anti-HBsAg ? 10 milli-International units per milliliter [mIU/mL]) to hepatitis B virus (HBV). Compare and contrast the cellular responses and gene expression patterns in healthy older adults after the first vs. second injection with HEPLISAV.
authorizations:
registration required
types:
Gene expression microarray data files
accessURL: https://www.immunespace.org/study/Studies/SDY299/dataset.view?datasetId=5014
landingPage: https://www.immunespace.org/project/Studies/SDY299/begin.view?
subject species: Homo sapiens
study conditions: Other
study type: Interventional
study category: Vaccine Response
assay type: Gene Expression
time point: 29-55
subject race: Asian
Black or African American
White
subject gender: Female
Male
subject age: 51-60
61-70
> 70
name:
Vaccine responses in healthy adult population.
affiliations:
Dynavax Technologies Corporation
fullName:
Robert Coffman
roles:
principal investigator
name:
Systems Biology Analysis of the response to Licensed Hepatitis B Vaccine (HEPLISAV) in Whole Blood (see companion studies SDY816 and SDY690)
size:
25
output:
Patterns of cellular responses and gene activation induced by HEPLISAV. Correlation of patterns of cellular and gene activation with anti-HBs antibody levels at various time points after injection.
description:
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
name:
ImmuneSpace
homePage: http://www.immunespace.org

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