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identifier: SDY368
description:
The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the inherent relationships between these components. Specifically, such knowledge requires an appreciation of B-Iymphocytes, T lymphocytes, natural killer cells and dendritic cells. Research investigating these cells and their functions necessitates the availability and acquisition of peripheral blood samples from healthy children to form control data groups against which various experimental conditions can be measured. Volunteers will be asked to donate blood samples to be used to further study the circulating dendritic cell subpopulations and establish their normal ranges. Blood samples will also be used to isolate antigen specific T lymphocytes, serve as a monocyte source and establish gene signatures.
aggregation:
instance of dataset
availability:
available with registration
acknowledges:
NIAID (HIPC funded)
isAbout:
1) which are the best biomarkers of immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner.
subject species: Homo sapiens
study conditions: Influenza
study type: Interventional
study category: Vaccine Response
assay type: HAI
Neutralizing Antibody
time point:
subject race: Black or African American
Other
White
subject gender: Female
Male
subject age: 0-10
11-20
name:
Vaccine Response in Healthy Children
affiliations:
NATIONWIDE CHILDREN'S HOSPITAL
fullName:
OCTAVIO RAMILO
roles:
principal investigator
name:
Systems Biology Approach to Study Influenza Vaccine 2013-14 in Healthy Children (see companion studies SDY364, SDY144, SDY387)
size:
22
output:
Establish normal ranges of dendritic cell subpopulation in healthy pediatric volunteers.
description:
To characterize the cellular and transcriptional signatures of response to Flu vaccine in healthy children.
name:
ImmuneSpace
homePage: http://www.immunespace.org

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