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identifier: SDY1041
description:
We present human T cell responses in multiple sites including blood, lymphoid, mucosal and secretory tissues of 20 CMV seropositive donors. Overall, CMV-specific T cells were maintained in distinct distribution patterns, either predominant in blood, bone marrow (BM) and lung, or lymph nodes (LN) with the frequency and function in blood distinct from tissues. Together, our results reveal tissue T cell reservoirs for CMV control, with global effects on T cell homeostasis over the human lifespan.
aggregation:
instance of dataset
availability:
available with registration
acknowledges:
NIAID, NIA, NCRR
primaryPublications: 28130404
isAbout:
Characterize tissue CMV-specific CD8 T-cell and polyclonal T cell phenotypes
subject species: Homo sapiens
study conditions: Other
study type: Observational
study category: Immune Response
assay type:
time point:
subject race: Asian
Black or African American
Not Specified
White
subject gender: Female
Male
subject age: 21-30
31-40
41-50
51-60
61-70
> 70
name:
CMV-specific T cell differentiation, homeostasis and persistence in blood, lymphoid, and mucosal tissues
affiliations:
Columbia University
fullName:
Donna Farber
roles:
principal investigator
name:
CMV CD8 T Cells
size:
20
output:
FCS data classifying T cells
description:
An analysis of human cytomegalovirus (CMV)-specific T cell responses and CMV persistence in multiple anatomic sites including blood, lymphoid, mucosal and secretory tissues of CMV-seropositive donors.
name:
ImmuneSpace
homePage: http://www.immunespace.org