Immunological Data Discovery Index
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identifier: SDY1097
description:
Knowledge of human immune responses during early life remains sparse, owing to the difficulty and impracticality of obtaining blood and tissue samples from infants. Our current view of normal infant immune responses, including T cell differentiation and function, is based mainly on the sampling of umbilical cord blood or fetal tissue, which reflect immune responses in utero but not responses to the diverse antigens encountered in early life. Fundamental information about the establishment of adaptive immunity during infancy, including how T cells respond, differentiate and populate tissue sites, remains undefined. Through collaboration with organ procurement agencies, we have established protocols for obtaining lymphoid and mucosal tissues from individual organ donors for whom consent has been given for the use of tissues for research.
aggregation:
instance of dataset
availability:
available with registration
acknowledges:
NIAID, NIA, NCRR, BD Bioscience
primaryPublications: 26657141
isAbout:
Characterize T cells from various tissues in infant vs young adult and adult humans
subject species: Homo sapiens
study conditions: Other
study type: Observational
study category: Immune Response
assay type:
time point:
subject race: Black or African American
Not Specified
White
subject gender: Female
Male
subject age: 0-10
11-20
21-30
31-40
41-50
51-60
61-70
name:
Age-specific T cell differentiation, homeostasis and persistence in blood, lymphoid, and mucosal tissues
affiliations:
Columbia University
fullName:
Donna Farber
roles:
principal investigator
name:
Early-life compartmentalization of human T cells
size:
43
output:
Flow cytometry data classifying T cells
description:
We present here an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ donors in the first two years of life, as compared to adult organ donors, revealing early compartmentalization of T cell differentiation and regulation.
name:
ImmuneSpace
homePage: http://www.immunespace.org

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