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identifier: SDY80
description:
The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases proposes this protocol designed to obtain blood from healthy adult subjects (NIH employees) prior to vaccination and then at various time points after receiving the FDA-licensed seasonal and H1N1 influenza vaccine. These samples will be used to perform a comprehensive and detailed analysis of the immune system at baseline and in response to vaccination. To our knowledge, this protocol will be the first study to characterize the human cellular and molecular immune system parameters, or immunome, in a large number of healthy adults (NIH employees). This information may be useful in designing newer, more effective vaccines to prevent the spread of H1N1 influenza.
aggregation:
instance of dataset
availability:
available with registration
acknowledges:
NIAID
primaryPublications: 24725414
isAbout:
The primary objective of this protocol is to perform a comprehensive and detailed analysis of the cellular and molecular immune responses in healthy adults at baseline, and after vaccination with either the seasonal H1N1 and the influenza vaccines. This will be the first study to systematically characterize the human immunome in a large number of healthy subjects (specifically NIH Employees). Furthermore, we anticipate that this protocol may provide information that may be useful in designing newer, more effective vaccines to prevent the spread of influenza, especially H1N1.
subject species: Homo sapiens
study conditions: Influenza
study type: Observational
study category: Vaccine Response
assay type: ELISPOT
Flow Cytometry
Gene Expression
Neutralizing Antibody
time point: <0
>56
subject race: Asian
Black or African American
Not Specified
Other
White
subject gender: Female
Male
Not Specified
subject age: 11-20
21-30
31-40
41-50
51-60
61-70
name:
Seasonal H1N1 vaccine response in healthy humans
affiliations:
NIH
fullName:
John Tsang
roles:
principal investigator
name:
Cellular and molecular characterization of the immune response in healthy NIH employees at baseline and after immunization with the H1N1 or seasonal influenza vaccines
size:
64
output:
The study endpoints consists of a set of research laboratory assessments.
description:
The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases proposes this protocol designed to obtain blood from healthy adult subjects (NIH employees) prior to vaccination and then at various time points after receiving the FDA-licensed seasonal and H1N1 influenza vaccine. These samples will be used to perform a comprehensive and detailed analysis of the immune system at baseline and in response to vaccination. To our knowledge, this protocol will be the first study to characterize the human cellular and molecular immune system parameters, or immunome, in a large number of healthy adults (NIH employees). This information may be useful in designing newer, more effective vaccines to prevent the spread of H1N1 influenza.
name:
ImmuneSpace
homePage: http://www.immunespace.org