Immunological Data Discovery Index
Advanced Search
identifier: 1418723
description:
epitope description:YGGPANKKNAG
antigen name:Merozoite surface protein 1
host organism:Aotus nancymaae
antibody name:Aotus sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 17403557
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1005960
landingPage: http://www.iedb.org/assay/1418723
type:
Literature
publicationVenue:
Vaccine
dates:
2007
study type: b cell assays
subject species: Plasmodium
fullName:
Adriana Bermú
dez
Claudia Reyes
Fanny Guzmá
n
Magnolia Vanegas
Jaiver Rosas
Roberto Amador
Raul Rodrí
guez
Manuel Alfonso Patarroyo
Manuel Elkin Patarroyo
method:
western blot
name:
Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization.
description:
The epitope residues were derived by sequencing the N-terminal region of 35K fragments of proteins isolated from schizont and merozoite lysates.
Sera from monkeys immunized with the chimeric SPf66 vaccine reacted with solubilized P. falciparum schizont antigens in western blot analysis. The reactivity with the cleavage products shown on the gel were consistent with the fragments from which the epitope was derived. The use of QS-21 as adjuvant with SPf66 instead of Freund's notably increased antibody titers.

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.