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identifier: 1418773
description:
epitope description:VFTGVLAGVWGEGGKFVYPFDDKMSFLFA
antigen name:DNA helicase/primase complex-associated protein
host organism:Mus musculus
antibody name:MAb 817, 818, 819
aggregation:
instance of dataset
availability:
available
primaryPublications: 9261356
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1004169
landingPage: http://www.iedb.org/assay/1418773
type:
Literature
publicationVenue:
J Virol
dates:
1997
study type: b cell assays
subject species: Human alphaherpesvirus 1
fullName:
H S Marsden
G W McLean
E C Barnard
G J Francis
K MacEachran
M Murphy
G McVey
A Cross
A P Abbotts
N D Stow
method:
biological activity
name:
The catalytic subunit of the DNA polymerase of herpes simplex virus type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex.
description:
All three of the mAbs that recognized the epitope in the C-terminus of UL8 were capable of inhibiting the interaction between UL8 (helicase-primase protein) and the polymerase (POL). The epitope was also shown to inhibit the interaction of the UL8 helicase to the POL polymerase directly. This was detected by POL-specific mAb 13185 in a separate assay (IC50 = 66uM).

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