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  1. A Cooperative Clinical Study of Abatacept in Multiple Sclerosis ITN TrialShare

    ID: ITN035AI

    Description: Background and Introduction Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal T-cell and ...

    Publication: 18794494; 27481207;
  2. High Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis ITN TrialShare

    ID: ITN033AI

    Description: This study is a prospective, multicenter Phase II clinical trial evaluating high-dose immunosuppressive therapy (HDIT) using Carmustine, Etoposide, Cy...

    Publication: 25546364; 24531550; 15302338; 16406806; 15738052; 15546956; 15958063; 18565456; 28148635; 28602891;
  3. Proleukin and Rapamune in Type 1 Diabetes ITN TrialShare

    ID: ITN018AI

    Description: At the time of diagnosis with type 1 diabetes, 15-40% of beta cells may remain active and healthy in the pancreas, capable of producing insulin the bo...

    Publication: 22721971; 24265670;
  4. Safety of RG2077 in Patients With Multiple Sclerosis ITN TrialShare

    ID: ITN006AI

    Description: This is an open-label, dose escalation, safety study. An initial group of 16 subjects who are diagnosed with relapsing-remitting MS will be enrolled o...

    Publication: 18794494;
  5. LEAP: Induction of Tolerance through Early Introduction of Peanut in High-Risk Children ITN TrialShare

    ID: ITN032AD

    Description: This is a randomized controlled trial in which children at high risk for peanut allergy (as demonstrated by eczema, egg allergy, or both) are enrolled...

    Publication: 23174658; 25705822; 16670515; 25956314; 26942922; 25705823; 27297994;
  6. Long-Term Effects of Sublingual Grass Therapy ITN TrialShare

    ID: ITN043AD

    Description: An estimated 45 million people in Europe have allergic rhinitis due to grass pollen allergy. Quality of life is often adversely affected by this condi...

    Publication: 29128670; 28196239; 28196255;
  7. Treatment With hOKT3gamma1(Ala-Ala) in T1DM ITN TrialShare

    ID: ITN007AI

    Description: This is a 2-arm, open-label Phase II trial involving 0 or 3 cycles of treatment, 6 months apart, with hOKT3γ1(Ala-Ala), over the first year of diseas...

    Publication: 19443276;
  8. Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis ITN TrialShare

    ID: ITN021AI

    Description: Current conventional therapies for ANCA-associated vasculitis (AAV) are associated with high incidences of treatment failure, disease relapse, substan...

    Publication: 23754238; 26882078; 25891759; 25776953; 25332071; 25047592; 25381429; 22975753; 22279570; 21953143; 23902481; 20647199; 23902488; 26387933; 26621483;
  9. Islet Transplantation for Type 1 Diabetes ITN TrialShare

    ID: ITN005CT

    Description: This is a single-arm, Phase I study, the primary objective of which is to cure diabetes mellitus by an injection of cellular graft into the liver. The...

    Publication: 17005949; 15257060; 23438305;
  10. Inducing Remission in Type 1 Diabetes With Alefacept ITN TrialShare

    ID: ITN045AI

    Description: The primary objective of this trial is to determine whether alefacept will slow the progression of the autoimmune destruction of β cells and lead to ...

    Publication: 26193635; 24622414; 24622404;
  11. Belatacept to Prevent Organ Rejection in Kidney Transplant Patients ITN TrialShare

    ID: ITN023ST

    Publication: 16120857;
  12. Islet Transplantation in Type 1 Diabetes ITN TrialShare

    ID: CIT-07

    Description: Type 1 diabetes is commonly treated with the administration of insulin, either by multiple insulin injections or by a continuous supply of insulin thr...

    Publication: ;
  13. Evaluation of a Diabetes Vaccine in Newly Diagnosed Diabetics ITN TrialShare

    ID: ITN012AI

    Description: This is a randomized, double-masked, 2-arm pilot study to monitor the safety of human insulin B-chain (IBC) peptide (BB-IND 8884) in subjects with typ...

    Publication: 19931408;
  14. Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) ITN TrialShare

    ID: ITN002AI

    Description: This trial comprises a dose-escalation portion and a randomized, controlled, open-label phase IIA portion that evaluate a single dose of CTLA4-IgG4m (...

    Publication: 15807196;
  15. Development of antigen-specific assays indicative of donor-specific tolerance in renal transplant recipients ITN TrialShare

    ID: ITN503ST

    Description: This study will attempt to establish the optimal (reproducibility and utility) in vitro assay/s for quantification and characterization of anti-donor ...

    Publication: ;
  16. Evaluation of Tolerability, Safety, and Pharmacokinetics of hOKt3γ1 (Ala-Ala) in Participants with Type 1 Diabetes Mellitus ITN TrialShare

    ID: ITN017AI

    Description: This study evaluated the safety and pharmacokinetics (PK) of hOKt3γ1 (Ala-Ala) in participants with Type 1 diabetes mellitus. A first group of 4 part...

    Publication: ;
  17. Persistence of Oral Tolerance to Peanut ITN TrialShare

    ID: ITN049AD

    Description: ITN049AD (LEAP-On) is a continuation of the ITN032AD LEAP Study. Peanut Allergy, a recognized public health concern, is a common and potentially life-...

    Publication: 26942922; 25705822; 25956314; 25705823;
  18. Treatment of Psoriatic Arthritis with hOKT3γ1 (Ala-Ala) ITN TrialShare

    ID: ITN011AI

    Description: Of the two currently available treatments for kidney failure, long-term dialysis and kidney transplantation, only kidney transplantation provides a po...

    Publication: ;
  19. Study of Antithymocyte Globulin for Treatment of New-onset T1DM ITN TrialShare

    ID: ITN028AI

    Description: This is a two-arm, 2:1 randomized, placebo-controlled, blinded, phase II trial. The clinical outcome variable proposed for clinical protocol ITN028AI ...

    Publication: 24622416; 14693724; 18628574; 27053235; 28198767;
  20. Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes ITN TrialShare

    ID: ITN027AI

    Description: Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks insulin-producing beta cells in the pancreas. Without these cel...

    Publication: 23835333; 28844471; 15919798; 12037148; 24115337;

Displaying 20 of 28 results for " "