Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY288 |
| description: |
A greater understanding of how alveolar macrophages respond to pathogens is important for the design of novel therapeutic agents for treatment of potentially lethal pulmonary infections. To increase understanding of early pulmonary infection response of mice following infection with viral and bacterial pathogen, alveolar macrophages were used to determine the similarities and differences between species to invading pulmonary pathogens
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
21789257 |
| isAbout: |
To develop and validate mathematical models of in vivo infection and ex vivo innate immune response of lung APCs to Francisella tularensis, Mycobacterium tuberculosis and influenza A virus
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| authorizations: |
registration required
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| accessURL: |
http://red.cs.pitt.edu/dataxs/ https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY288 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY288 |
| clinical trial: | |
| study category: | Immune Response |
| study type: | Observational |
| subject species: | Mus musculus |
| biosample type: |
Cell Organ |
| subject gender: | Not Specified |
| assay type: |
Cell Culture DNA microarray ELISPOT Flow Cytometry Luminex xMAP |
| name: |
Immune response to pathogen
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| fullName: |
Penelope Morel
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| affiliations: |
University of Pittsburgh
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| roles: |
principal investigator
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| name: |
Modeling Pulmonary Immunity: Evaluation of the Innate Immune Response to Pathogens 1) Francisella tularensis 2) Mycobacterium tuberculosis and 3) Influenza A virus in mice (C57BL/6 and BALB/c)
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| size: |
876
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| name: |
University of Pittsburgh Center for Modeling Immunity for Biodefense
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| output: |
Assay lung APC immune response to pathogens and validate mathematical models
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| studyGroups: |
Arm_E16G Elderly Lethal PR8: Arm_E16G Elderly Lethal PR8
Arm_Acute Infection Exp. 1: Arm_Acute Infection Exp. 1
Arm_Acute infection Exp. 2: Arm_Acute infection Exp. 2
Arm_Acute Infection Exp. 3: Arm_Acute Infection Exp. 3
Arm_Acute Infection Exp. 4: Arm_Acute Infection Exp. 4
Arm_Acute Infection Exp. 5: Arm_Acute Infection Exp. 5
Arm_Acute Infection Exp. 6: Arm_Acute Infection Exp. 6
Arm_Acute Infection Exp. 7: Arm_Acute Infection Exp. 7
Arm_Acute Infection Exp. 8: Arm_Acute Infection Exp. 8
Arm_Adenovirus Exp. 2: Arm_Adenovirus Exp. 2
Arm_Adult: Arm_Adult
Arm_Advenovirus Exp. 1: Arm_Advenovirus Exp. 1
Arm_Aged: Arm_Aged
Arm_E16K Adult Sublethal PR8: Arm_E16K Adult Sublethal PR8
Arm_Elderly: Arm_Elderly
Arm_Experiment 6: Arm_Experiment 6
Arm_experiment 7: Arm_experiment 7
Arm_experiment 9: Arm_experiment 9
Arm_expt 4: Arm_expt 4
Arm_expt 5: Arm_expt 5
Arm_Francisella Tularensis Live Vaccine Strain: Arm_Francisella Tularensis Live Vaccine Strain
Arm_Francisella Tularensis N/A: Arm_Francisella Tularensis N/A
Arm_Francisella Tularensis Schu S4: Arm_Francisella Tularensis Schu S4
Arm_HIV-1 VLP (ADA): Arm_HIV-1 VLP (ADA)
Arm_Influenza A A/Brisbane/59/2007: Arm_Influenza A A/Brisbane/59/2007
Arm_Influenza A A/Mexico/4108/2009: Arm_Influenza A A/Mexico/4108/2009
Arm_Influenza A A/PR: Arm_Influenza A A/PR
Arm_Influenza A A/PR-DelNS1: Arm_Influenza A A/PR-DelNS1
Arm_Influenza A A/WS/Mongolia/244/2005: Arm_Influenza A A/WS/Mongolia/244/2005
Arm_Influenza A Fujian: Arm_Influenza A Fujian
Arm_Influenza A H5-Indo: Arm_Influenza A H5-Indo
Arm_Influenza A H5-PR8: Arm_Influenza A H5-PR8
Arm_Influenza A HINI (A/CA/07): Arm_Influenza A HINI (A/CA/07)
Arm_Influenza A New Caledonia: Arm_Influenza A New Caledonia
Arm_Influenza A New Caledonia (M/A): Arm_Influenza A New Caledonia (M/A)
Arm_Influenza A Shanghai-B: Arm_Influenza A Shanghai-B
Arm_Influenza A Solomon Island: Arm_Influenza A Solomon Island
Arm_Influenza A Vietnam: Arm_Influenza A Vietnam
Arm_Influenza A Wisconsin: Arm_Influenza A Wisconsin
Arm_Mycobacterium Tuberculosis Erdman: Arm_Mycobacterium Tuberculosis Erdman
Arm_Mycobacterium Tuberculosis H37Rv: Arm_Mycobacterium Tuberculosis H37Rv
Arm_Rift Valley Fever virus MP12: Arm_Rift Valley Fever virus MP12
Arm_Rift Valley Fever virus ZH501: Arm_Rift Valley Fever virus ZH501
Arm_Uninfected PBS: Arm_Uninfected PBS
Arm_Vaccination Exp. 1: Arm_Vaccination Exp. 1
Arm_Vaccination Exp. 2: Arm_Vaccination Exp. 2
Arm_Vaccination Exp. 3: Arm_Vaccination Exp. 3
Arm_Vaccination Exp. 4: Arm_Vaccination Exp. 4
Arm_Vaccination Exp. 5: Arm_Vaccination Exp. 5
Arm_Vaccination Exp. 6: Arm_Vaccination Exp. 6
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| description: |
Alveolar macrophages from mice and macaques following infection with viral and bacterial pathogens were used to determine the similarities and differences to invading pulmonary pathogens
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| identifier: |
10.21430/M3H9VMI0DF
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
