Immune Responses to Seasonal TIV 2010-2011 Influenza Vaccination in Humans (see companion study SDY396,SDY564)

Title:

Immune Responses to Seasonal TIV 2010-2011 Influenza Vaccination in Humans (see companion study SDY396,SDY564)

identifier:	SDY224
description:	High-frequency sampling combined with systems biology analysis of human peripheral blood cells following influenza vaccination was used to investigate T cell and B cell responses. Functional principal component analysis was used to examine time varying B cell vaccine response highlighting a single subject-specific mathematical pattern explaining ninety percent of the transcriptome variation. In addtition, daily sampling and monitoring of the proliferation marker Ki-67, revealed influenza-specific CD4 T cells do respond to vaccination.
aggregation:	instance of dataset
refinement:	2 - Complete set of descriptive data and results, as ascertained by ImmPort.
availability:	available with registration
primaryPublications:	23900141 22554464
isAbout:	Develop detailed, multi-level, multi-scale high dimensional mathematical models of the immune response to seasonal influenza vaccination

authorizations:	registration required
accessURL:	https://cbim.urmc.rochester.edu/ http://www.ncbi.nlm.nih.gov/sra?term=SRX259436 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE45764 https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY224
landingPage:	http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY224

clinical trial:
study category:	Immune Response Vaccine Response
study type:	Interventional
subject species:	Homo sapiens
biosample type:	Cell Serum
subject gender:	Both
assay type:	ELISA ELISPOT Flow Cytometry Hemagglutination Inhibition Q-PCR Sequencing

name:	immune response in healthy volunteers

fullName:	Hulin Wu Martin Zand
affiliations:	University of Rochester Medical Center
roles:	principal investigator

name:	Immune Responses to Seasonal TIV 2010-2011 Influenza Vaccination in Humans (see companion study SDY396,SDY564)
size:	14

name:	University of Rochester Center for Biodefense Immune Modeling II
output:	Blood samples prior to vaccination and daily sampling post vaccination up to 10 days and day 21
studyGroups:	TIV 2010: Subjects receiving TIV seasonal vaccine in the 2010-2011 influenza season
description:	To use system biology approaches to compare differences in immune responses to vaccine
identifier:	10.21430/M37KMO7JLW

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