Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY25 |
| description: |
The goal of this study is to create a pool of potential subjects genotyped in a manner identical to that used in the AVA000 trial population.
Subjects were screened for exclusion based on history of chronic infectious or immune diseases and to avoid sampling during current acute infection. Genotyping data are available for reference purposes. The subjects agreed to be available to be recalled for sampling of blood for ex vivo studies of differential immunologic function of genetic variants corresponding to those associated with variation in vaccine response.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
21368772 |
| isAbout: |
To create a pool of potential subjects genotyped in a manner identical to that used in the AVA000 trial population.
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| authorizations: |
registration required
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| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY25 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY25 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Observational |
| subject species: | Homo sapiens |
| biosample type: |
DNA Other Serum |
| subject gender: | Both |
| assay type: |
ELISA Other PCR |
| name: |
Genotyping and gene function in healthy volunteers.
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| fullName: |
Richard Kaslow
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| affiliations: |
University of Alabama at Birmingham
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| roles: |
principal investigator
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| name: |
Genotyping and gene function in healthy volunteers
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| size: |
1426
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| name: |
Population Genetics Analysis Program: Immunity to Vaccines/Infections
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| output: |
Genotyping - iSelect Bead Chip (Illumina)
Genotyping - HLA class I and II by PCR-based techniques
Genotyping - Pyrosequencing
Genotyping - ABI SNPlex
Genotyping - Genome-wide association study
Flow cytometric response to anthrax vaccine (AVA)
Genotyping - PCR for insertion polymorphism
Protein expression - Serum immunoglobulin levels
Quantification of serum cytokines and chemokines
Protein expression - Flow cytometry
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| studyGroups: |
Genotyping and gene function in healthy volunteers: Adult volunteers interviewed screened, and recruited to donate a sample of blood for genotying and cryopreservation
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| description: |
Functionally important genetic variants (certain naturally occurring SNPs) in a set of candidate genes that are known to be relevant for immune response to protein antigens, are expected to be associated with AbPA response and B-cell physiology.
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| identifier: |
10.21430/M3L5GO913J
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
