Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY26 |
| description: |
The overall goal of this contract is to identify genetic differences that increase the risk for a major adverse event associated with smallpox vaccination - myocarditis - and to determine the mechanism by which these genetic differences confer risk.
|
| aggregation: |
instance of dataset
|
| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
|
| availability: |
available with registration
|
| isAbout: |
To identify polymorphisms associated with risk for the development of myopericarditis following smallpox vaccine in a case/control study design.
|
| authorizations: |
registration required
|
| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY26 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY26 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Observational |
| subject species: | Homo sapiens |
| biosample type: | DNA |
| subject gender: | Both |
| assay type: |
HLA Typing Other SNP microarray |
| name: |
Vaccinia-peptides, myocarditis, DC-mediated activation
|
| fullName: |
Christopher Wilson
|
| affiliations: |
University of Washington
|
| roles: |
principal investigator
|
| name: |
Identify polymorphisms associated with risk for the development of myopericarditis following smallpox vaccine
|
| size: |
413
|
| name: |
Genetic Risk for Smallpox Vaccine Related to Myocarditis
|
| output: |
Genome wide SNP genotyping.
Identify HLA genes associated with risk of developing myocarditis post-smallpox vaccination.
Analysis of chromatin profile by DNase I hypersensitive sites in isolated human immune cell types from healthy blood donors.
Resequencing of SNPs associated regions in candidate genes.
|
| studyGroups: |
Primary Case Group: Develop myopericarditis within 30 days of receiving smallpox vaccination.
Control Group: Unaffected after smallpox vaccination.
Unknown Status: Status unknown after smallpox vaccination.
|
| description: |
The overall goal of this contract is to identify genetic differences that increase the risk for a major adverse event associated with smallpox vaccination - myocarditis - and to determine the mechanism by which these genetic differences confer risk.
|
| identifier: |
10.21430/M389L5FQCN
|
| startDate: |
2010-08-04
|
| name: |
ImmPort
|
| identifier: |
SCR:012804
|
| homePage: |
http://www.immport.org |
