Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY261 |
| description: |
the human protease genes required for influenza virus replication were determined and validated using RNA interference approaches. The genes validated as critical for influenza virus replication were ADAMTS7, CPE, DPP3, MST1, and PRSS12, and pathway analysis showed these genes were in global host cell pathways governing inflammation (NF-kB), cAMP/calcium signaling (CRE/CREB), and apoptosis.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
22606348 |
| isAbout: |
Identify host genes and microRNAs important for influenza replication providing potential new targets for disease intervention strategies
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| authorizations: |
registration required
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| accessURL: |
www.medicine.emory.edu/ipirc https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY261 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY261 |
| clinical trial: | |
| study category: | Immune Response |
| study type: | Interventional |
| subject species: | Homo sapiens |
| biosample type: | Cell |
| subject gender: | Male |
| assay type: |
Liquid Chromatography Other Q-PCR TCID50 Transcription profiling assay |
| name: |
Influenza
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| fullName: |
Ralph Tripp
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| affiliations: |
Department of Infectious Diseases, University of Georgia
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| roles: |
principal investigator
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| name: |
MicroRNA Regulation of Human Protease Genes
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| size: |
1
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| name: |
Influenza Pathogenesis & Immunology Research Center (IPIRC)
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| output: |
gene expression during virus replication
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| studyGroups: |
VM12-PO-Arm: A549 cells (ATCC CCL-185) were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone, Logan, UT) containing 5% heat-inactivated FBS (HyClone, Logan, UT). Cells were frozen in 10% DMSO and 90% FBS to create one stock of a single cell passage that was used for the entire screen.
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| description: |
the human protease genes required for influenza virus replication were determined and validated using RNA interference approaches. The genes validated as critical for influenza virus replication were ADAMTS7, CPE, DPP3, MST1, and PRSS12, and pathway analysis showed these genes were in global host cell pathways governing inflammation (NF-kB), cAMP/calcium signaling (CRE/CREB), and apoptosis.
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| identifier: |
10.21430/M3KPHZF88E
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
