Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY1043 |
| description: |
In this work, we present a new algorithm that employs local search techniques to discover statistically significant patient-specific motifs in large-scale immune-repertoire datasets. We apply our methodology successfully to our multi-million-sequence immune repertoire dataset to discover a statistically significant MS-specific motif. The discovered sequence motif could potentially serve as biomarker for the clinical diagnosis of Multiple Sclerosis. The presented methodology is efficient and generalizable to other high throughput sequencing datasets.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| isAbout: |
Identify disease-only motifs from blood-based B-cell DNA
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| authorizations: |
registration required
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| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY1043 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY1043 |
| clinical trial: | |
| study category: | Immune Response |
| study type: | Observational |
| subject species: | Homo sapiens |
| biosample type: | PBMC |
| subject gender: | Both |
| assay type: | RNA sequencing |
| name: |
Multiple sclerosis
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| fullName: |
Marina Sirota
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| affiliations: |
University of California San Francisco
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| roles: |
principal investigator
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| name: |
A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data
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| size: |
97
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| name: |
Antibody Mediated Autoimmunity in Neuromyelitis Optica
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| output: |
None
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| studyGroups: |
Healthy control: Healthy control
Untreated: MS-diagnosed, untreated
Avonex: MS-diagnosed, Avonex treated
Copaxone: MS-diagnosed, Copaxone treated
Rebif: MS-diagnosed, Rebif treated
Natalizumab: MS-diagnosed, Natalizumab treated
Betaseron: MS-diagnosed, Betaseron treated
Neurontin, Vitamin D: MS-diagnosed, Neurontin, Vitamin D treated
Copaxone, Vitamin D: MS-diagnosed, Copaxone, Vitamin D treated
Interferons - Rebif: MS-diagnosed, Interferons - Rebif treated
Interferons - Avonex: MS-diagnosed, Interferon - Avonex treated
Rebif, ivIG: MS-diagnosed, Rebif, ivIG treated
Vitamin D: MS-diagnosed, Vitamin D treated
Rituximab: MS-diagnosed, Rituximab treated
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| description: |
The authors applied high-throughput sequencing of blood-based B-cell DNA from healthy control and multiple sclerosis patients and used a computational method, the Haystack Heuristic, to query and analyze data for B-cell related disease biomarkers
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| identifier: |
10.21430/M3HUHJSPBP
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| startDate: |
2011-01-01
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
