Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY1173 |
| description: |
A genome wide association study was performed in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome. Samples from three Nordic data sets (involving a total of 8643 women) were used to test for replication of genomic loci that had significant genome wide association (P<5.0?10?8) or an association with suggestive significance (P<1.0?10?6) in the discovery set. Four loci were associated significantly with gestational duration, and three showed association with preterm birth with genome wide significance. An analysis of mother?infant dyads suggested that these variants act at the level of the maternal genome. Data is shared at http://www.genestation.org/analysis/gwas/Zhang_2017/discovery
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
28877031 |
| isAbout: |
This study tested for genetic associations with gestational duration (a quantitative trait) as well as preterm birth (a dichotomous trait) in a large cohort of subjects to increase statistical power to detect genome wideassociation.
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| authorizations: |
registration required
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| accessURL: |
https://researchers.23andme.org/published-data http://www.genestation.org/analysis/gwas/Zhang_2017/discoveryhttps://aspera-immport.niaid.nih.gov:9443/browser?path=SDY1173 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY1173 |
| clinical trial: | |
| study category: | No Research Focus Specified |
| study type: | Observational |
| subject species: | |
| biosample type: | |
| subject gender: | Female-Child pairs |
| assay type: |
| name: |
Gestational duration and preterm birth
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| fullName: |
Bo Jacobsson
Louis Muglia
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| affiliations: |
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden
Cincinnati Children?s Hospital Medical Center
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| roles: |
principal investigator
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| name: |
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
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| output: |
GWAS data
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| studyGroups: |
Discovery data set: GWAS discovery data set
Replication data set: GWAS replication data set
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| description: |
This study identified four loci involved in gestational duration and three with preterm birth through a genome-wide association screen performed on a discovery data set and confirmed with a replication data set.
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| identifier: |
10.21430/M3F345ZL81
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| startDate: |
1997-01-01
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
