Live Lung Donor Cross-sectional Cohort Study (RELIVE-05) | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Live Lung Donor Cross-sectional Cohort Study (RELIVE-05)

Dataset

identifier:	SDY294
description:	The Live Lung Donor Cross-sectional Cohort Study (RELIVE-05) aimed to determine the effects of live lung donation on lung function, quality of life, morbidity, psychosocial status, satisfaction with live lung donation, and decision-making associated with live lung donation. This study built on the separate but related RELIVE-02 retrospective study that assessed the effects of live lung donation on survival and short-term morbidity. This multicenter cross-sectional cohort study invited the RELIVE-02 living former live lung donors to undergo questionnaire and pulmonary function test assessments to further determine the long-term outcomes of live lung donation. This study used preoperative donor pulmonary function data and normative data to assist with assessing the effects of live lung donation on lung donors.
aggregation:	instance of dataset
refinement:	2 - Complete set of descriptive data and results, as ascertained by ImmPort.
availability:	available with registration
primaryPublications:	25039865
isAbout:	The primary objective of this study is to determine the effects of live lung donation on lung function, relative to baseline lung function, normative values, and expected decline associated with aging. The secondary objectives of this study are: To estimate quality of life (general and disease-specific) following live lung donation and compare current status to normative data. To estimated long-term morbidity after live lung donation and determine whether live lung donation is associated with increased risk of long-term morbidity relative to normative data. To assess the post-donation psychosocial status and compare current status to normative data. To assess satisfaction with live lung donation. To assess decision-making associated with live lung donation. To assess the representiveness of the participating live lung donor study sample by comparing baseline donor characteristics, short-term safety (i.e., morbidity) and recipient outcomes from RELIVE-02, for donors that participate fully, partially, or not at all in RELIVE-05. To conduct exploratory multivariable analyses, after adjusting for key variables, to assess for predictors of donor outcome / status.

Access

authorizations:	registration required
accessURL:	http://www.clinicaltrials.gov/ct2/show/NCT01524835 http://projectreporter.nih.gov/project_info_details.cfm?aid=7259520&icde=26163672 https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY294
landingPage:	http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY294

Dimension

clinical trial:	clinical trial
study category:	Transplantation
study type:	Observational
subject species:	Homo sapiens
biosample type:
subject gender:	Both
assay type:

Disease

name:	Lung Transplantation

Person

fullName:	Mark Barr
affiliations:	University of Southern California
roles:	principal investigator

Study Group

name:	Live Lung Donor Cross-sectional Cohort Study (RELIVE-05)
size:	162

Study

name:	CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
output:	The primary endpoint of this study is spirometric lung function (forced expiratory volume in 1 second [FEV1]).The secondary endpoints of this study are: Quality of life (general and disease-specific). Morbidity (short and long-term). Psychosocial status. Anxiety symptoms. Depression symptoms. Satisfaction with live lung donation. Decision-making associated with live lung donation. Representiveness of participating live lung donor study sample. Predictors of donor outcome/status.
studyGroups:	Live lung donors: Live lung donors who participated in donation from 1993 through 2006
description:	The Live Lung Donor Cross-sectional Cohort Study (RELIVE-05) aimed to determine the effects of live lung donation on lung function, quality of life, morbidity, psychosocial status, satisfaction with live lung donation, and decision-making associated with live lung donation. This study built on the separate but related RELIVE-02 retrospective study that assessed the effects of live lung donation on survival and short-term morbidity. This multicenter cross-sectional cohort study invited the RELIVE-02 living former live lung donors to undergo questionnaire and pulmonary function test assessments to further determine the long-term outcomes of live lung donation. This study used preoperative donor pulmonary function data and normative data to assist with assessing the effects of live lung donation on lung donors.
identifier:	10.21430/M38LFF1QAA
startDate:	2010-08-01

Data Repository

name:	ImmPort
identifier:	SCR:012804
homePage:	http://www.immport.org

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