Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY675 |
| description: |
The adaptive immune systems capability to protect the body requires a highly diverse lymphocyte antigen receptor repertoire. However, the influence of individual genetic and epigenetic differences on these repertoires is frequently underestimated. By leveraging the unique characteristics of B, CD4+ T, and CD8+ T lymphocyte subsets isolated from monozygotic twins, we have elucidated the impact of heritable factors on the V(D)J recombination process and have shown that the repertoires of both naive and antigen experienced cells are subject to biases resulting from initial recombination differences. Moreover, we show that the relative usage of V and J gene segments is chromosomally biased, with approximately 1.5 times as many rearrangements originating from a single chromosome. These data refine our understanding of the heritable mechanisms affecting the repertoire, and show that bias exists on a chromosome-wide level.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
27005435 |
| isAbout: |
Determine the genetic and epigentic influence on the B cell and T cell receptor repertoire.
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| authorizations: |
registration required
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| accessURL: |
http://www.ncbi.nlm.nih.gov/bioproject/PRJNA300878 http://wiki.vdjserver.org/vdjserver/index.php/Rubelt_et_al._2016 https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY675 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY675 |
| clinical trial: | |
| study category: | Immune Response |
| study type: | Observational |
| subject species: | Homo sapiens |
| biosample type: | RNA |
| subject gender: | Both |
| assay type: | RNA sequencing |
| name: |
Healthy monozygotic twins without recent vaccination in their 20s, both genders.
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| fullName: |
Mark M Davis
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| affiliations: |
Stanford University
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| roles: |
principal investigator
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| name: |
Heritable influence on the B and T cell receptor repertoire
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| size: |
10
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| name: |
Vaccination and infection: indicators of immunological health and responsiveness
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| output: |
B and T cell receptor sequences
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| studyGroups: |
Healthy monozygotic twins without recent vaccination: Healthy monozygotic twins without recent vaccination in their 20s, both genders.
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| description: |
Determing the individual heritable differences result in unique B and T cell receptor repertoires of naive and antigen-experienced cells through next gerneration sequencing.
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| identifier: |
10.21430/M3XMYVQI9X
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| startDate: |
2010-01-01
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
