Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY33 |
| description: |
A prospective longitudinal study comparing renal transplant patients with controls to determine the biological mechanisms that underlie the immunosuppressed state associated with immunosuppressive regimens after transplantation.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
21220454 18449194 19247287 |
| isAbout: |
To determine the effects of chronic immunosuppressive therapies on adaptive immunity: Effects on the phenotype and functional properties of T cell and B cell subsets and antigen-specific T cells.
To determine the effects of chronic immunosuppressive therapies on innate immunity, dendritic cell phenotype, function and TLR signaling.
To define the transcriptional signatures associated with specific immunosuppressive regimens.
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| authorizations: |
registration required
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| accessURL: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039865/ https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY33 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY33 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Observational |
| subject species: | Homo sapiens |
| biosample type: |
Cell Other RNA |
| subject gender: | Both |
| assay type: |
DNA microarray ELISPOT Flow Cytometry HLA Typing |
| name: |
Assessment of vaccine response in chronically immunosuppressed renal transplant patients.
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| fullName: |
Christian Larsen
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| affiliations: |
Emory Transplant Center
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| roles: |
principal investigator
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| name: |
Impact of immunosuppressive regimens on protective immunity in renal transplant recipients
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| size: |
116
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| name: |
Protective Immunity in Transplant Recipients
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| output: |
HLA genotyping of enrolled subjects.
FCM experiment to measure frequency and phenotypic profile of B and T cell subsets in chronically immunosuppressed patients.
CD107A degranulation assay to assess numbers and function of antigen-specific memory T cells in chronic immunosuppression.
CFSE proliferation assay to assess numbers and function of antigen-specific memory T cells in chronic immunosuppression.
ELISPOT assay to assess memory B cell function in renal transplant patients with tacrolimus and sirolimus treatment.
ELISA serum antibody titers to assess memory B cell function in renal transplant patients with tacrolimus and sirolimus treatment.
Effects of chronic immunosuppression on dendritic cell function.
Microarray experiment to define the transcriptional signatures associated with specific immunosuppressive regimens.
Viral monitoring by PCR.
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| studyGroups: |
De novo transplant, No Induction, Tacrolimus Maintenance: De novo Renal Transplant Patients, No Induction Therapy, Tacrolimus Maintenance
De novo transplant, No Induction, Sirolimus Maintenance: De novo Renal Transplant Patients, No Induction Therapy, Sirolimus Maintenance
De novo transplant, With Induction, Tacrolimus Maintenance: De novo Renal Transplant Patients, With Induction Therapy, Tacrolimus Maintenance
De novo transplant, With Induction, Sirolimus Maintenance: De novo Renal Transplant Patients, With Induction Therapy, Sirolimus Maintenance
De novo transplant, With Induction, Efalizumab Maintenance: De novo Renal Transplant Patients, With Induction, Efalizumab Maintenance
Donor (surgical) Controls: Healthy donor (surgical) controls
Healthy Controls: Healthy controls
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| description: |
A prospective longitudinal study to determine biological mechanisms that underlie the immunosuppressed state associated with immunosuppressive regimens after renal transplantation.
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| identifier: |
10.21430/M3TJ6DJLEY
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
