Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY35 |
| description: |
A detailed mechanistic study of the immune response to vaccinia vaccine in immunosuppressed Rhesus macaques and development of a relevant preclinical model in which the efficacy and safety of vaccines in the setting of transplantation can be evaluated.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| primaryPublications: |
21342450 |
| isAbout: |
Describe Rhesus cellular response to VV and map epitopes in MHC-typed macaques.
To compare the magnitude and character of immune responses (T and B cell responses and molecular signature) after immunization with the MVA in macaques receiving CNI or sirolimus-based immunosuppressive regimens relative to untreated controls.
To determine whether prior immunization with replication deficient MVA enhances the response to and improves viral control after VV challenge in immunosuppressed macaques.
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| authorizations: |
registration required
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| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY35 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY35 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Observational |
| subject species: | Macaca mulatta |
| biosample type: |
Cell Other RNA |
| subject gender: | Both |
| assay type: |
DNA microarray ELISA Flow Cytometry |
| name: |
Assessment of Modified Vaccinia Ankara and Vaccinia vaccine responses in Rhesus Macaques receiving CNI-based or sirolimus-based immunosuppressive regimens without renal allografts.
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| fullName: |
Christian Larsen
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| affiliations: |
Emory Transplant Center
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| roles: |
principal investigator
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| name: |
Responses to and control of vaccinia in immunosuppressed Rhesus Macaques
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| size: |
19
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| name: |
Protective Immunity in Transplant Recipients
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| output: |
PCR monitoring of viral load.
FCM experiment to measure frequency and phenotypic profile of T cell subsets in rhesus macaques.
ELISPOT assay to assess memory B cell function in rhesus macaques with tacrolimus and sirolimus treatment.
ELISA serum antibody titers to assess memory B cell function in rhesus macaques with tacrolimus and sirolimus treatment.
FCM experiment to study effects of vaccination on renal allograft in rhesus macaques.
ELISPOT experiment to study effects of vaccination on renal allograft in rhesus macaques.
Microarray gene expression analysis.
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| studyGroups: |
No ISD + VV + MVA: Rhesus Macaques not receiving any immunosuppressant drugs but receive Vaccinia Vaccine (VV) and the Modified Vaccinia Ankara (MVA) vaccine.
No ISD + MVA + MVA: Rhesus Macaques not receiving any immunosuppressant drugs but receive the Modified Vaccinia Ankara (MVA) vaccine.
CNI + MVA + MVA: Rhesus Macaques receiving CNI-based immunosuppressant receiving Modified Vaccinia Ankara (MVA) vaccinations.
Sirolimus + MVA + MVA: Rhesus Macaques receiving sirolimus-based immunosuppressant receiving Modified Vaccinia Ankara (MVA) vaccinations.
Sirolimus + VV + MVA: Rhesus Macaques receiving sirolimus-based immunosuppressant receiving Vaccinia Vaccine (VV) and Modified Vaccinia Ankara (MVA) vaccine.
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| description: |
To study the immune response to vaccinia vaccine in immunosuppressed Rhesus macaques and to develop a relevant preclinical model in which the efficacy and safety of vaccines in the setting of transplantation can be evaluated.
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| identifier: |
10.21430/M381YQIYXY
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
