Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY368 |
| description: |
The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the inherent relationships between these components. Specifically, such knowledge requires an appreciation of B-Iymphocytes, T lymphocytes, natural killer cells and dendritic cells. Research investigating these cells and their functions necessitates the availability and acquisition of peripheral blood samples from healthy children to form control data groups against which various experimental conditions can be measured. Volunteers will be asked to donate blood samples to be used to further study the circulating dendritic cell subpopulations and establish their normal ranges. Blood samples will also be used to isolate antigen specific T lymphocytes, serve as a monocyte source and establish gene signatures.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| isAbout: |
1) which are the best biomarkers of immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner.
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| authorizations: |
registration required
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| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY368 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY368 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Interventional |
| subject species: | Homo sapiens |
| biosample type: |
Serum Whole blood |
| subject gender: | Both |
| assay type: |
DNA microarray Flow Cytometry Hemagglutination Inhibition Virus Neutralization |
| name: |
Vaccine Response in Healthy Children
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| fullName: |
OCTAVIO RAMILO
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| affiliations: |
NATIONWIDE CHILDREN'S HOSPITAL
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| roles: |
principal investigator
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| name: |
Systems Biology Approach to Study Influenza Vaccine 2013-14 in Healthy Children (see companion studies SDY364, SDY144, SDY387)
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| size: |
22
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| name: |
Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
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| output: |
Establish normal ranges of dendritic cell subpopulation in healthy pediatric volunteers.
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| studyGroups: |
NCH-2013-14: TIV Vaccine
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| description: |
To characterize the cellular and transcriptional signatures of response to Flu vaccine in healthy children.
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| identifier: |
10.21430/M3VUYLMJSR
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| startDate: |
2013-08-12
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
