Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY376 |
| description: |
This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population.
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| aggregation: |
instance of dataset
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| refinement: |
2 - Complete set of descriptive data and results, as ascertained by ImmPort.
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| availability: |
available with registration
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| isAbout: |
This Project will study vaccine responses in sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine (in collaboration with Dr. Ramillo's study for healthy children and here for patients with JDM); 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population
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| authorizations: |
registration required
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| accessURL: |
https://aspera-immport.niaid.nih.gov:9443/browser?path=SDY376 |
| landingPage: |
http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY376 |
| clinical trial: | |
| study category: | Vaccine Response |
| study type: | Interventional |
| subject species: | Homo sapiens |
| biosample type: |
Serum Whole blood |
| subject gender: | Both |
| assay type: |
DNA microarray Flow Cytometry Hemagglutination Inhibition Virus Neutralization |
| name: |
Vaccine response in pediatric patients with juvenile dermatomyositis (JDM)
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| fullName: |
Virginia Pascual
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| affiliations: |
Baylor Institute for Immunology Research
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| roles: |
principal investigator
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| name: |
Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2013/2014 Cohort (see companion studies SDY369, SDY372, SDY645)
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| size: |
13
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| name: |
Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
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| output: |
To gain a comprehensive view of the immune alterations associated with a potent response to flu vaccination using immunological and system biology approaches.
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| studyGroups: |
JDM_2013-2014: TIV Vaccine
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| description: |
Transcriptional profiling of peripheral blood of pediatric patients with juvenile dermatomyositis (JDM) before/after vaccination with seasonal influenza vaccine (Fluzone)
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| identifier: |
10.21430/M37IMDD0RO
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| startDate: |
2009-09-09
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| name: |
ImmPort
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| identifier: |
SCR:012804
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| homePage: |
http://www.immport.org |
