Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY515 |
| description: |
Evaluate the variation in immune response between individuals and assess whether it changes as a function of age and similarity in genetic and environmental background (by comparing differences between monozygotic and dizygotic twin pairs of different ages).
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID (HIPC funded)
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| relatedIdentifiers: |
SDY514
SDY519
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| primaryPublications: |
25594173 |
| isAbout: |
Compare lymphocyte responses at Days 7-10 and the lymphocyte and serology responses at Day 28 post-immunization following annual administration of the influenza vaccines; Evaluate changes in cytokine profile in the immune response (CD4, CD8,and B cell responses) from Day 0 to Day 7-10 for T cells and antibody-secreting cells (ASCs); Evaluate changes in cytokine profile in the immune response from Day 0 to Day 28 for HAI responses to the vaccine antigens; Evaluate any potential gene expression signatures either at Day 0 or during the early response period Day 7-10 that are associated with immune senescence, potentially providing insight into mechanism; Identify age-specific biomarkers or clusters of markers in general and especially those that are predictive of immune sufficiency or insufficiency.
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| authorizations: |
registration required
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| types: |
Flow cytometry analyzed results
Hemagglutination inhibition (HAI)
Multiplex bead array asssay
FCS control files
FCS sample files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY515/dataset.view?datasetId=5017 https://www.immunespace.org/study/Studies/SDY515/dataset.view?datasetId=5005 https://www.immunespace.org/study/Studies/SDY515/dataset.view?datasetId=5008 https://www.immunespace.org/study/Studies/SDY515/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY515/dataset.view?datasetId=5018 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY515/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Interventional |
| study category: |
Immune Response Vaccine Response |
| assay type: |
CyTOF Flow Cytometry HAI MBAA |
| time point: | Unknown |
| subject race: |
American Indian or Alaska Native Asian Black or African American Not Specified Other White |
| subject gender: |
Female Male Not Specified |
| subject age: |
0-10 11-20 21-30 41-50 51-60 > 70 |
| name: |
Influenza Vaccine Response
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| affiliations: |
Stanford University
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| fullName: |
Mark Davis
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| roles: |
principal investigator
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| name: |
Monozygotic and Dizygotic Twin Pair T-Cell Responses to Influenza Vaccination 2010
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| size: |
84
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| output: |
conclusion reached
|
| description: |
Evaluate the variation in immune response between individuals and assess whether it changes as a function of age and similarity in genetic and environmental background (by comparing differences between monozygotic and dizygotic twin pairs of different ages).
|
| name: |
ImmuneSpace
|
| homePage: |
http://www.immunespace.org |
