Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY180 |
| alternateIdentifiers: |
GSE30101
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| description: |
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points af- ter vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumo- coccal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID (HIPC funded)
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| primaryPublications: |
23601689 |
| isAbout: |
Our aim is to apply systems biology approaches to study immune responses to vaccination with seasonal influenza and 23-valent pneumococcal vaccine in healthy adults. This in turn will permit us to define vaccine responders and non-responders and develop biomarker signatures predictive of vaccine response.
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| authorizations: |
registration required
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| types: |
Flow cytometry analyzed results
Hemagglutination inhibition (HAI)
Multiplex bead array asssay
Neutralizing antibody titer
FCS control files
FCS sample files
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5017 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5005 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5008 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5009 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5018 https://www.immunespace.org/study/Studies/SDY180/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY180/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Interventional |
| study category: | Vaccine Response |
| assay type: |
Flow Cytometry Gene Expression HAI MBAA Neutralizing Antibody |
| time point: |
Unknown <0 15-27 |
| subject race: |
Asian Black or African American White |
| subject gender: |
Female Male |
| subject age: |
21-30 31-40 41-50 |
| name: |
Healthy adults- longitudinal follow-up
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| affiliations: |
Baylor Reasearch Institute
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| fullName: |
A. Karolina Palucka
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| roles: |
principal investigator
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| name: |
Systems scale interactive exploration reveals quantitative and qualitative differences in response to 2009-2010 Fluzone influenza vaccine and pneumococcal vaccine
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| size: |
46
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| output: |
Serological outcome
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| description: |
Systems approach to study immune response to seasonal influenza and 23-valent pneumoccocal vaccination in healthy adults.
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
