Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY224 |
| alternateIdentifiers: |
GSE45764
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| description: |
High-frequency sampling combined with systems biology analysis of human peripheral blood cells following influenza vaccination was used to investigate T cell and B cell responses. Functional principal component analysis was used to examine time varying B cell vaccine response highlighting a single subject-specific mathematical pattern explaining ninety percent of the transcriptome variation. In addtition, daily sampling and monitoring of the proliferation marker Ki-67, revealed influenza-specific CD4 T cells do respond to vaccination.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID
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| relatedIdentifiers: |
SDY241
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| primaryPublications: |
22554464 23900141 |
| isAbout: |
Develop detailed, multi-level, multi-scale high dimensional mathematical models of the immune response to seasonal influenza vaccination
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| authorizations: |
registration required
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| types: |
Enzyme-linked immunosorbent assay (ELISA)
Enzyme-Linked ImmunoSpot (ELISPOT)
Flow cytometry analyzed results
Hemagglutination inhibition (HAI)
Polymerisation chain reaction (PCR)
FCS control files
FCS sample files
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5003 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5004 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5017 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5005 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5010 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5018 https://www.immunespace.org/study/Studies/SDY224/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY224/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Interventional |
| study category: |
Immune Response Vaccine Response |
| assay type: |
ELISA ELISPOT Flow Cytometry Gene Expression HAI PCR |
| time point: |
<0 15-27 |
| subject race: |
American Indian or Alaska Native Black or African American White |
| subject gender: |
Female Male |
| subject age: |
21-30 31-40 41-50 |
| name: |
immune response in healthy volunteers
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| affiliations: |
University of Rochester Medical Center
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| fullName: |
Martin Zand, Hulin Wu
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| roles: |
principal investigator
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| name: |
Immune Responses to Seasonal TIV 2010-2011 Influenza Vaccination in Humans (see companion study SDY396,SDY564)
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| size: |
14
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| output: |
Blood samples prior to vaccination and daily sampling post vaccination up to 10 days and day 21
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| description: |
To use system biology approaches to compare differences in immune responses to vaccine
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
