Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY299 |
| description: |
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID (HIPC funded)
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| isAbout: |
Document the changes in cellular responses and gene expression patterns in serial blood samples collected from healthy older adults after vaccination with HEPLISAV. Determine which of these changes correlate with the development of protective levels of antibody (anti-HBsAg ? 10 milli-International units per milliliter [mIU/mL]) to hepatitis B virus (HBV). Compare and contrast the cellular responses and gene expression patterns in healthy older adults after the first vs. second injection with HEPLISAV.
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| authorizations: |
registration required
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| types: |
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY299/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY299/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Other |
| study type: | Interventional |
| study category: | Vaccine Response |
| assay type: | Gene Expression |
| time point: | 29-55 |
| subject race: |
Asian Black or African American White |
| subject gender: |
Female Male |
| subject age: |
51-60 61-70 > 70 |
| name: |
Vaccine responses in healthy adult population.
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| affiliations: |
Dynavax Technologies Corporation
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| fullName: |
Robert Coffman
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| roles: |
principal investigator
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| name: |
Systems Biology Analysis of the response to Licensed Hepatitis B Vaccine (HEPLISAV) in Whole Blood (see companion studies SDY816 and SDY690)
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| size: |
25
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| output: |
Patterns of cellular responses and gene activation induced by HEPLISAV. Correlation of patterns of cellular and gene activation with anti-HBs antibody levels at various time points after injection.
|
| description: |
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
|
| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
