Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY387 |
| description: |
The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the inherent relationships between these components. Specifically, such knowledge requires an appreciation of B-Iymphocytes, T lymphocytes, natural killer cells and dendritic cells. Research investigating these cells and their functions necessitates the availability and acquisition of peripheral blood samples from healthy children to form control data groups against which various experimental conditions can be measured. Volunteers will be asked to donate blood samples to be used to further study the circulating dendritic cell subpopulations and establish their normal ranges. Blood samples will also be used to isolate antigen specific T lymphocytes, serve as a monocyte source and establish gene signatures.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID (HIPC funded)
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| relatedIdentifiers: |
SDY74
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| primaryPublications: |
23486778 |
| isAbout: |
1) which are the best biomarkers of immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner.
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| authorizations: |
registration required
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| types: |
Flow cytometry analyzed results
Hemagglutination inhibition (HAI)
Neutralizing antibody titer
FCS control files
FCS sample files
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5017 https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5005 https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5009 https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5018 https://www.immunespace.org/study/Studies/SDY387/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY387/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Interventional |
| study category: | Vaccine Response |
| assay type: |
Flow Cytometry Gene Expression HAI Neutralizing Antibody |
| time point: |
29-55 >56 |
| subject race: |
Asian Black or African American White |
| subject gender: |
Female Male |
| subject age: |
0-10 11-20 Unknown |
| name: |
Vaccine Response in Healthy Children
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| affiliations: |
Nationwide Children's Hospital
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| fullName: |
Octavio Ramilo
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| roles: |
principal investigator
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| name: |
Systems Biology Approach to Study Influenza Vaccine 2010-11 in Healthy Children (see companion studies SDY144, SDY368, SDY387)
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| size: |
22
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| output: |
Establish normal ranges of dendritic cell subpopulation in healthy pediatric volunteers.
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| description: |
To characterize the cellular and transcriptional signatures of response to Flu vaccine in healthy children.
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
