Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY690 |
| description: |
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID (HIPC funded)
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| isAbout: |
Document the changes in cellular responses and gene expression patterns in serial blood samples collected from healthy older adults after vaccination with Engerix-B. Determine which of these changes correlate with the development of protective levels of antibody (anti-HBsAg ? 10 milli-International units per milliliter [mIU/mL]) to hepatitis B virus (HBV). Compare and contrast the cellular responses and gene expression patterns in healthy older adults after the first vs. second injection with Engerix-B.
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| authorizations: |
registration required
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| types: |
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY690/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY690/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Other |
| study type: | Interventional |
| study category: | Vaccine Response |
| assay type: | Gene Expression |
| time point: | 29-55 |
| subject race: | White |
| subject gender: |
Female Male |
| subject age: |
51-60 61-70 |
| name: |
Vaccine responses in healthy adult population.
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| affiliations: |
Dynavax Technologies Corporation
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| fullName: |
Robert Coffman
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| roles: |
principal investigator
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| name: |
Systems Biology Study to Investigate Immune Correlates to Hepatitis B Vaccine Engerix-B comparing cellular responses and gene expression patterns between PBMCs (cell sorts) and whole blood samples (see companion studies SDY816 and SDY299)
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| size: |
12
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| output: |
Patterns of cellular responses and gene activation induced by Engerix-B. Correlation of patterns of cellular and gene activation with anti-HBs antibody levels at various time points after injection.
|
| description: |
This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
|
| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
