Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Defective signaling in aging |
| identifier: | SDY887 |
| description: |
Pilot year. Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an effort to indentify benchmarks of immunological health, influenza vaccination was used in 10 young (20-30 years) and 19 older subjects (60 to 89 years) as models for strong and weak immune responses, respectively. Serological responses to influenza strains as well as a wide variety of other parameters, including gene expression, antibodies to hemagglutinin peptides, serum cytokines, cell subset phenotypes and in vitro cytokine stimulation were measured. Using machine learning, nine variables predicting antibody response with 84% accuracy were identified. Two of these variables are involved in apoptosis, which positively associated with the response to vaccination and was confirmed to be a contributor to vaccine responsiveness in mice. The identification of these biomarkers provides new insights into what immune features may be most important for immune health.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
Ellison Foundation (HIPC funded)
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| relatedIdentifiers: |
SDY212
SDY312
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| primaryPublications: |
27746093 |
| isAbout: |
To assess variability in immune features between young and old and among older adults
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| authorizations: |
registration required
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| types: |
Flow cytometry analyzed results
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY887/dataset.view?datasetId=5017 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY887/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Longitudinal |
| study category: | Vaccine Response |
| assay type: | Flow Cytometry |
| time point: | |
| subject race: |
Asian Other White |
| subject gender: |
Female Male |
| subject age: |
21-30 61-70 > 70 |
| name: |
Influenza vaccine
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| affiliations: |
Stanford University
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| fullName: |
Cornelia Dekker
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| roles: |
principal investigator
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| name: |
Defective signaling in aging
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| size: |
26
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| output: |
Blood baseline characterization using whole genome DNA microarrays . Cytokine and chemokine analysis using multiplexed serum protein assays . High-resolution immune phenotyping for 15 immune cell subsets . Capture antibody response measurements to TIV . Capture signaling response measurements to cytokines in various cell subsets from peripheral blood, using antibodies to phosphorylated STAT proteins, also known as phosphoFlow (pFlow).
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| description: |
In an effort to identify benchmarks of immunological health, influenza vaccination was used in 10 young (20 to 30 years) and 19 older subjects (60 to 89 years) as models for strong and weak immune responses, respectively.
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |