Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | CMV CD8 T Cells |
| identifier: | SDY1041 |
| description: |
We present human T cell responses in multiple sites including blood, lymphoid, mucosal and secretory tissues of 20 CMV seropositive donors. Overall, CMV-specific T cells were maintained in distinct distribution patterns, either predominant in blood, bone marrow (BM) and lung, or lymph nodes (LN) with the frequency and function in blood distinct from tissues. Together, our results reveal tissue T cell reservoirs for CMV control, with global effects on T cell homeostasis over the human lifespan.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID, NIA, NCRR
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| primaryPublications: |
28130404 |
| isAbout: |
Characterize tissue CMV-specific CD8 T-cell and polyclonal T cell phenotypes
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| authorizations: |
registration required
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| types: |
FCS control files
FCS sample files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY1041/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY1041/dataset.view?datasetId=5018 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY1041/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Other |
| study type: | Observational |
| study category: | Immune Response |
| assay type: | |
| time point: | |
| subject race: |
Asian Black or African American Not Specified White |
| subject gender: |
Female Male |
| subject age: |
21-30 31-40 41-50 51-60 61-70 > 70 |
| name: |
CMV-specific T cell differentiation, homeostasis and persistence in blood, lymphoid, and mucosal tissues
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| affiliations: |
Columbia University
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| fullName: |
Donna Farber
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| roles: |
principal investigator
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| name: |
CMV CD8 T Cells
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| size: |
20
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| output: |
FCS data classifying T cells
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| description: |
An analysis of human cytomegalovirus (CMV)-specific T cell responses and CMV persistence in multiple anatomic sites including blood, lymphoid, mucosal and secretory tissues of CMV-seropositive donors.
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |