Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY1097 |
| description: |
Knowledge of human immune responses during early life remains sparse, owing to the difficulty and impracticality of obtaining blood and tissue samples from infants. Our current view of normal infant immune responses, including T cell differentiation and function, is based mainly on the sampling of umbilical cord blood or fetal tissue, which reflect immune responses in utero but not responses to the diverse antigens encountered in early life. Fundamental information about the establishment of adaptive immunity during infancy, including how T cells respond, differentiate and populate tissue sites, remains undefined. Through collaboration with organ procurement agencies, we have established protocols for obtaining lymphoid and mucosal tissues from individual organ donors for whom consent has been given for the use of tissues for research.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID, NIA, NCRR, BD Bioscience
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| primaryPublications: |
26657141 |
| isAbout: |
Characterize T cells from various tissues in infant vs young adult and adult humans
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| authorizations: |
registration required
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| types: |
FCS control files
FCS sample files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY1097/dataset.view?datasetId=5019 https://www.immunespace.org/study/Studies/SDY1097/dataset.view?datasetId=5018 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY1097/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Other |
| study type: | Observational |
| study category: | Immune Response |
| assay type: | |
| time point: | |
| subject race: |
Black or African American Not Specified White |
| subject gender: |
Female Male |
| subject age: |
0-10 11-20 21-30 31-40 41-50 51-60 61-70 |
| name: |
Age-specific T cell differentiation, homeostasis and persistence in blood, lymphoid, and mucosal tissues
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| affiliations: |
Columbia University
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| fullName: |
Donna Farber
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| roles: |
principal investigator
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| name: |
Early-life compartmentalization of human T cells
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| size: |
43
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| output: |
Flow cytometry data classifying T cells
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| description: |
We present here an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ donors in the first two years of life, as compared to adult organ donors, revealing early compartmentalization of T cell differentiation and regulation.
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| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
