Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | SDY80 |
| description: |
The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases proposes this protocol designed to obtain blood from healthy adult subjects (NIH employees) prior to vaccination and then at various time points after receiving the FDA-licensed seasonal and H1N1 influenza vaccine. These samples will be used to perform a comprehensive and detailed analysis of the immune system at baseline and in response to vaccination. To our knowledge, this protocol will be the first study to characterize the human cellular and molecular immune system parameters, or immunome, in a large number of healthy adults (NIH employees). This information may be useful in designing newer, more effective vaccines to prevent the spread of H1N1 influenza.
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| aggregation: |
instance of dataset
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| availability: |
available with registration
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| acknowledges: |
NIAID
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| primaryPublications: |
24725414 |
| isAbout: |
The primary objective of this protocol is to perform a comprehensive and detailed analysis of the cellular and molecular immune responses in healthy adults at baseline, and after vaccination with either the seasonal H1N1 and the influenza vaccines. This will be the first study to systematically characterize the human immunome in a large number of healthy subjects (specifically NIH Employees). Furthermore, we anticipate that this protocol may provide information that may be useful in designing newer, more effective vaccines to prevent the spread of influenza, especially H1N1.
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| authorizations: |
registration required
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| types: |
Enzyme-Linked ImmunoSpot (ELISPOT)
Flow cytometry analyzed results
Neutralizing antibody titer
Gene expression microarray data files
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| accessURL: |
https://www.immunespace.org/study/Studies/SDY80/dataset.view?datasetId=5004 https://www.immunespace.org/study/Studies/SDY80/dataset.view?datasetId=5017 https://www.immunespace.org/study/Studies/SDY80/dataset.view?datasetId=5009 https://www.immunespace.org/study/Studies/SDY80/dataset.view?datasetId=5014 |
| landingPage: |
https://www.immunespace.org/project/Studies/SDY80/begin.view? |
| subject species: | Homo sapiens |
| study conditions: | Influenza |
| study type: | Observational |
| study category: | Vaccine Response |
| assay type: |
ELISPOT Flow Cytometry Gene Expression Neutralizing Antibody |
| time point: |
<0 >56 |
| subject race: |
Asian Black or African American Not Specified Other White |
| subject gender: |
Female Male Not Specified |
| subject age: |
11-20 21-30 31-40 41-50 51-60 61-70 |
| name: |
Seasonal H1N1 vaccine response in healthy humans
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| affiliations: |
NIH
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| fullName: |
John Tsang
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| roles: |
principal investigator
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| name: |
Cellular and molecular characterization of the immune response in healthy NIH employees at baseline and after immunization with the H1N1 or seasonal influenza vaccines
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| size: |
64
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| output: |
The study endpoints consists of a set of research laboratory assessments.
|
| description: |
The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases proposes this protocol designed to obtain blood from healthy adult subjects (NIH employees) prior to vaccination and then at various time points after receiving the FDA-licensed seasonal and H1N1 influenza vaccine. These samples will be used to perform a comprehensive and detailed analysis of the immune system at baseline and in response to vaccination. To our knowledge, this protocol will be the first study to characterize the human cellular and molecular immune system parameters, or immunome, in a large number of healthy adults (NIH employees). This information may be useful in designing newer, more effective vaccines to prevent the spread of H1N1 influenza.
|
| name: |
ImmuneSpace
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| homePage: |
http://www.immunespace.org |
