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Title: Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1.
identifier: 1464105
description:
epitope description:T11, F31, S57, S113, I114
antigen name:Bet v 1
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 16293967
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1005357
landingPage: http://www.iedb.org/assay/1464105
type:
Literature
publicationVenue:
Int Arch Allergy Immunol
dates:
2006
study type: b cell assays
subject species: Betula pendula
fullName:
Yan Ma
Gabriele Gadermaier
Barbara Bohle
Suzanne Bolhaar
Andre Knulst
Zora Markovic-Housley
Heimo Breiteneder
Peter Briza
Karin Hoffmann-Sommergruber
Fatima Ferreira
method:
ELISA
name:
Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1.
description:
Sera IgE from patients allergic to apples showed lower reactivity to a mutant Bet v 1 with the discontinuous epitope residues mutated, as compared to wild type Bet v 1, by both Western blot and ELISA, demonstrating the importance of these residues in antigenicity.

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