Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Title:

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Dataset

identifier:	1379481
description:	epitope description:ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYI antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:1G10
aggregation:	instance of dataset
availability:	available
primaryPublications:	16378996

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004752
landingPage:	http://www.iedb.org/assay/1379481

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2006

Dimension

study type:	b cell assays
subject species:	SARS coronavirus

Person

fullName:	Kuo-Ming Lip Shuo Shen Xiaoming Yang Choong-Tat Keng Aihua Zhang Hsueh-Ling Janice Oh Zhi-Hong Li Le-Ann Hwang Chih-Fong Chou Burtram C Fielding Timothy H P Tan Josef Mayrhofer Falko G Falkner Jianlin Fu Seng Gee Lim Wanjin Hong Yee-Joo Tan

Data Type

method:	western blot

Study

name:	Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.
description:	The epitope was mapped by noting binding and lack of binding to various fragments of the SARS S protein.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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