Isotype-specific immune response to a single hepatitis C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR.

Title:

Isotype-specific immune response to a single hepatitis C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR.

Dataset

identifier:	1379756
description:	epitope description:VYLLPR antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	8086507

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004809
landingPage:	http://www.iedb.org/assay/1379756

Publication

type:	Literature
publicationVenue:	Ann Hematol
dates:	1994

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	K Siemoneit M da Silva Cardoso A Wö lpl S Epple H Wintersinger K Koerner B Kubanek

Data Type

method:	ELISA

Study

name:	Isotype-specific immune response to a single hepatitis C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR.
description:	The seroreactivity of anti-HCV-reactive blood donors to the epitope was examined. Over 80% of samples that had RIBA reactivity to all four recombinant HCV antigens or to c22-3/c33c showed reactivity to the peptide. In contrast, antibodies to the peptide were detected in less than 10% of the samples having RIBA reactivity to c22-3/c100-3 or a RIBA indeterminate pattern with reactivity only to c22-3.The anti-peptide response correlated with the presence ofHCV RNA in 95.5% of the samples.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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