Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective.

Title:

Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective.

Dataset

identifier:	1380773
description:	epitope description:PLGFFPDHQLDPAFGANSNNPDWDFNP + MYRI(G3) antigen name:Large envelope protein host organism:Oryctolagus cuniculus antibody name:Rabbit anti-preS (21-47) sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	2476893

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004733
landingPage:	http://www.iedb.org/assay/1380773

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	1989

Dimension

study type:	b cell assays
subject species:	Hepatitis B virus subtype adw2

Person

fullName:	A R Neurath B Seto N Strick

Data Type

method:	biological activity

Study

name:	Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective.
description:	Anti-epitope [preS(21-47)] sera produced in rabbits was mixed with HBV and then injected into chimpanzees in an in vivo neutralization assay. One out of two chimpanzees remained uninfected, suggesting that the anti-sera was neutralizing.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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