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Title: Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody.
identifier: 1380989
description:
epitope description:AGDRAGDRAGDRAGDRAGDRAGDR
host organism:Aotus trivirgatus
antibody name:Aotus monkey sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 1471743
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1004840
landingPage: http://www.iedb.org/assay/1380989
type:
Literature
publicationVenue:
Am J Trop Med Hyg
dates:
1992
study type: b cell assays
subject species:
fullName:
T R Jones
L F Yuan
H A Marwoto
D M Gordon
R A Wirtz
S L Hoffman
method:
ELISA
name:
Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody.
description:
The peptide is a hexamer of four consecutive amino acids found in the repeat sequence of the circumsporozoite protein of several strains of Plasmodium vivax.
Sera from 2 immunized monkeys reacted with the epitope but not with the recombinant protein VIVAX-1, which contains monomeric AGDR and approximately 60% of the CS protein from P. vivax strain Belem. Preincubation of the sera with the epitope, but not VIVAX-1, removed antibody reactivity.

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