Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1004807 |
| landingPage: |
http://www.iedb.org/assay/1382059 |
| type: |
Literature
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| publicationVenue: |
J Med Virol
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| dates: |
1996
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| study type: | b cell assays |
| subject species: |
| fullName: |
Y Nakamoto
S Kaneko
H Ohno
M Honda
M Unoura
S Murakami
K Kobayashi
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| method: |
ELISA
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| name: |
B-cell epitopes in hypervariable region 1 of hepatitis C virus obtained from patients with chronic persistent hepatitis.
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| description: |
The peptide is an analog of the consensus sequence from a variable region (residues 396-402) in hypervariable domain 1 (HVR1) within the N-terminus of the HCV E2 protein. The epitope matches a natural sequence (residues 69-75 of GenBank accession no. 60544262).
After treatment with IFN-alpha2b, serum from a patient with chronic HCV recognized this analog epitope. The pre- and post-IFN serum from the patient were tested against a panel of 143 substituted analogs of the consensus peptide TSGLTSL. The patient's sera did not react with the consensus peptide.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
