Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1.

Title:

Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1.

Dataset

identifier:	1383011
description:	epitope description:PPTAPPLLPHSNL antigen name:Envelope glycoprotein gp62 host organism:Homo sapiens antibody name:KE36-11
aggregation:	instance of dataset
availability:	available
primaryPublications:	1378869

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004069
landingPage:	http://www.iedb.org/assay/1383011

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1992

Dimension

study type:	b cell assays
subject species:	Human T-lymphotropic virus 1

Person

fullName:	M Kuroki M Nakamura Y Itoyama Y H Shiraki E Baba T Tatsumoto S Nagafuchi S Nakano et al.

Data Type

method:	antigen inhibition

Study

name:	Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1.
description:	Epitope was deduced from antibody binding assays using overlapping oliogpeptides spanning amino acids 175-200. Soluble peptide env gp46 175-199 (FLNTEPSQLPPTAPPLLPHSNLDHI), which contains the epitope, abolished inhibition of HTLV-1-induced syncytium formation by the mAb. .

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.