Immunological Data Discovery Index
Advanced Search
  1. << Go Back
Title: Delineation of contiguous determinants essential for biological functions of the pre-S sequence of the hepatitis B virus envelope protein: its antigenicity, immunogenicity and cell-receptor recognition.
identifier: 1383758
description:
epitope description:MQWNSTAFHQTLQDPRVRGLYLPAGGSSSGTVNP
antigen name:Large envelope protein
host organism:Mus musculus
antibody name:F376
aggregation:
instance of dataset
availability:
available
primaryPublications: 2462893
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1004871
landingPage: http://www.iedb.org/assay/1383758
type:
Literature
publicationVenue:
Ann Inst Pasteur Virol
dates:
1988
study type: b cell assays
subject species: Hepatitis B virus subtype adw2
fullName:
A R Neurath
S B Kent
N Strick
K Parker
method:
ELISA
name:
Delineation of contiguous determinants essential for biological functions of the pre-S sequence of the hepatitis B virus envelope protein: its antigenicity, immunogenicity and cell-receptor recognition.
description:
The sequence is derived from cited reference (AR Neurath, et al. (1987) Mol. Immunol. 24:975-80
[PMID: 3657811]).
The epitope was identified as an optimal epitope. Elongation of shorter peptide or addition of cystein or glycine at N-terminal of peptides increased Ab binding. Similar results were obtained with radio labeled mAb. Peptide residue substitution with alanine indicated essential binding domain was located between Q132 and L139.

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.

ImmuneData is supported by the NIAID, Grant HHSN272201700019C. Privacy

ImmuneData is developed by TechWave International, Inc. and UT Health Science Center at Houston