Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.

Title:

Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.

identifier:	1390531
description:	epitope description:LDERPYCWHYPPRP antigen name:Genome polyprotein host organism:Rattus norvegicus antibody name:6/41a
aggregation:	instance of dataset
availability:	available
primaryPublications:	10400713

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

fullName:	M Flint C Maidens L D Loomis-Price C Shotton J Dubuisson P Monk A Higginbottom S Levy J A McKeating

method:	biological activity

name:	Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.
description:	The epitope sequence was deduced through study of maltose binding protein-E2 fusion proteins and overlapping peptides. This mAb is able to bind a recombinant E2 (N-ter 278-aa) in ELISA, but not if it is bound to human CD81-expressing Rat basophilic leukemia (RBL) cells, and E2-mAb preincubation inhibits the E2-CD81-RBL interaction. This data suggest this region is involved in E2-CD81 interaction.

name:	iedb
homePage:	http://www.iedb.org

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