Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1004911 |
| landingPage: |
http://www.iedb.org/assay/1397563 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2003
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus (isolate H77) |
| fullName: |
Mayla Hsu
Jie Zhang
Mike Flint
Carine Logvinoff
Cecilia Cheng-Mayer
Charles M Rice
Jane A McKeating
|
| method: |
biological activity
|
| name: |
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles.
|
| description: |
The epitope sequence was deduced through study of maltose binding protein-E2 fusion proteins and overlapping peptides. These mAb inhibit the infectivity of HIV pseudotypes expressing the HCV E1 and E2 glycoproteins to the human hepatoma cell line Huh-7.5. mAb 2/69a is able to neutralize over 99% of the infectious particles, while 1/39 inhibits 20% at 10μg/ml. .
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |