Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1004948 |
| landingPage: |
http://www.iedb.org/assay/1402825 |
| type: |
Literature
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| publicationVenue: |
Hepatology
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| dates: |
2007
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| study type: | b cell assays |
| subject species: | Hepatitis C virus (isolate H77) |
| fullName: |
Joseph Torresi
Owen M Stock
Alexandra E Fischer
Lara Grollo
Heidi Drummer
Irene Boo
Weiguang Zeng
Linda Earnest-Silveira
David C Jackson
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| method: |
biological activity
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| name: |
A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virus.
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| description: |
This epitope sequence was reported as being from the HVR1 region of HCV H77 1a, however, an internal ID was assigned because no match could be found by BLAST.
Antisera from mice immunized with the epitope linked to a helper epitope exhibited greater inhibition of the entry of HCV pseudotypic particles into Huh 7 cells than sera from mice immunized with a lipidated polyepitope vaccine which consists of 4 component peptides representing sequence variants of HCV H77 HVR1, a T helper epitope, and Pam2Cys linked to create a heteropolymer.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
