Identification of Hendra virus G glycoprotein residues that are critical for receptor binding. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.

Dataset

identifier:	1403268
description:	epitope description:K443, K465 antigen name:Glycoprotein G host organism:Mus musculus BALB/c antibody name:H2.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	17376907

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004952
landingPage:	http://www.iedb.org/assay/1403268

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2007

Dimension

study type:	b cell assays
subject species:	Hendra henipavirus

Person

fullName:	Kimberly A Bishop Tzanko S Stantchev Andrew C Hickey Dimple Khetawat Katharine N Bossart Valery Krasnoperov Parkash Gill Yan Ru Feng Lemin Wang Bryan T Eaton Lin-Fa Wang Christopher C Broder

Data Type

method:	immunoprecipitation

Study

name:	Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.
description:	A panel of conformation-dependent mAbs was tested by radioimmunoprecipitation. The neutralizing mAb H2.1 lost binding reactivity to HeV G glycoprotein mutants with alanine substitution at epitope residues. The epitope (and additional D257, D260, G439, G449, and D468) residues are critical for HeV G binding to its receptors ephrinB2 and ephrinB3, and interaction with HeV F for membrane fusion.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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