Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1403284 |
| description: |
epitope description:R426, S432, T433, Y436, N437, K439, Y440, Y442, P469, P470, A471, L472, N473, C474, Y475, W476, L478, N479, D480, Y481, G482, Y484, T485, T486, T487, G488, I489, Y491, Q492
antigen name:Spike glycoprotein
host organism:Homo sapiens
antibody name:80R
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
16954221 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002494 |
| landingPage: |
http://www.iedb.org/assay/1403284 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | SARS coronavirus |
| fullName: |
William C Hwang
Yaqiong Lin
Eugenio Santelli
Jianhua Sui
Lukasz Jaroszewski
Boguslaw Stec
Michael Farzan
Wayne A Marasco
Robert C Liddington
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| method: |
x-ray crystallography
|
| name: |
Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.
|
| description: |
Antibody 80R neutralizes all SARS-CoVs and SARS-like CoVs that evolved during the 2002-2003 outbreak. except SARS-like CoVs from civet cats containing the D480G mutation. 80R antibody doesn't bind these mutants. 80R binds S1 with nanomolar affinity, blocks the binding of S1 to ACE2, prevents the formation of syncytia in vitro, and inhibits viral replication in vivo.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
