Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus.

Title:

Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus.

Dataset

identifier:	1403754
description:	epitope description:ANETIYNTTLKYGDV antigen name:Envelope glycoprotein B host organism:Homo sapiens antibody name:AE11F
aggregation:	instance of dataset
availability:	available
primaryPublications:	12504553

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004655
landingPage:	http://www.iedb.org/assay/1403754

Publication

type:	Literature
publicationVenue:	Virology
dates:	2003

Dimension

study type:	b cell assays
subject species:	Human herpesvirus 5 strain AD169

Person

fullName:	Johan Lantto Jean M Fletcher Mats Ohlin

Data Type

method:	antigen inhibition

Study

name:	Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus.
description:	The epitope specific antibody was assayed against alanine-substituted peptides to assess the ability of the analogs to inhibit binding to the wild-type peptide. Certain positions totally abrogated the inhibiting capacity of the peptide when replaced by an alanine, including Y72, T75, L76, and Y78.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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