Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Vaccination by cholera toxin conjugated to a herpes simplex virus type 2 glycoprotein D peptide. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1005830 |
| landingPage: |
http://www.iedb.org/assay/1409528 |
| type: |
Literature
|
| publicationVenue: |
J Gen Virol
|
| dates: |
1992
|
| study type: | b cell assays |
| subject species: | Human alphaherpesvirus 2 |
| fullName: |
M D Drew
A Estrada-Correa
B J Underdown
M R McDermott
|
| method: |
in vivo assay
|
| name: |
Vaccination by cholera toxin conjugated to a herpes simplex virus type 2 glycoprotein D peptide.
|
| description: |
Mice immunized with the gD(1-23)-CTX conjugate were protected (60-70%) from a lethal i.p. and intravaginal challenge with HSV-2. Thus, ip/ip or ip/ig immunization with the epitope conjugate elicits antiviral antibody in vaginal washings and correlates with significant protection from lethal i.v. challenge with HSV-2. A cysteine was added to the C-terminus of the peptide to facilitate the conjugation of CTX or horse spleen ferritin.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |