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Title: Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2 beta protein in patients with chronic Chagas' heart disease.
identifier: 1410812
description:
epitope description:EEEDDDMGFGLFD
antigen name:Other Trypanosoma cruzi protein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 15147356
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1005864
landingPage: http://www.iedb.org/assay/1410812
type:
Literature
publicationVenue:
Clin Exp Immunol
dates:
2004
study type: b cell assays
subject species: Trypanosoma cruzi
fullName:
E Mahler
J Hoebeke
M J Levin
method:
antigen inhibition
name:
Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2 beta protein in patients with chronic Chagas' heart disease.
description:
The epitope inhibited binding of purified mono-specific anti-epitope Abs to the epitope-BSA conjugate. Peptide H13 (aa: EESDDDMGFGLFD) and it's phospho-serine analogue inhibited the binding as well. Alanine substitution assay revealed the fine-specificity of purified mono-specific Abs had unique recognition patterns with one common residue of E3 for binding.

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