An experimental and modeling-based approach to locate IgE epitopes of plant profilin allergens. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

An experimental and modeling-based approach to locate IgE epitopes of plant profilin allergens.

Dataset

identifier:	1416098
description:	epitope description:LGDYLIEQGL antigen name:Other Cucumis melo (Oriental melon) protein host organism:Homo sapiens antibody name:patient sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	17397911

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005027
landingPage:	http://www.iedb.org/assay/1416098

Publication

type:	Literature
publicationVenue:	J Allergy Clin Immunol
dates:	2007

Dimension

study type:	b cell assays
subject species:	Cucumis melo

Person

fullName:	Gema Ló pez-Torrejó n Araceli Dí az-Perales Julia Rodrí guez Rosa Sá nchez-Monge Jesus F Crespo Gabriel Salcedo Luis F Pacios

Data Type

method:	western blot

Study

name:	An experimental and modeling-based approach to locate IgE epitopes of plant profilin allergens.
description:	IgE from a serum pool and from one or more of 4 individual sera from patients with melon allergy reacted strongly with the epitope. Based on 3D modeling and analysis of solvent exposure and electrostatic properties, the authors identified the epitope sequence as part of a complex epitope, E2 (residues 95-99 and 122-131), which partially overlaps with the actin binding site.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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