Molecular and structural analysis of the panallergen profilin B cell epitopes defined by monoclonal antibodies.

Title:

Molecular and structural analysis of the panallergen profilin B cell epitopes defined by monoclonal antibodies.

identifier:	1416705
description:	epitope description:YDEPVAPG antigen name:Hel a 2 host organism:Mus musculus BALB/c antibody name:9G4
aggregation:	instance of dataset
availability:	available
primaryPublications:	12202397

study type:	b cell assays
subject species:	Helianthus annuus

fullName:	Juan A Asturias Nuria Gó mez-Bayó n M Carmen Arilla Luis Sá nchez-Pulido Alfonso Valencia Alberto Martí nez

method:	western blot

name:	Molecular and structural analysis of the panallergen profilin B cell epitopes defined by monoclonal antibodies.
description:	The epitope sequence recognized by mAb 9G4 was deduced through study of overlapping peptides spanning the Hel a 2 allergen. MAb 9G4 reacted with the overlapping peptides GIYDEPVAPG and YDEPVAPGQC. Single amino acid substitutions established residues Y108, V112, and P114 to be critical for antibody binding.

name:	iedb
homePage:	http://www.iedb.org

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