Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus.

Title:

Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus.

Dataset

identifier:	1418705
description:	epitope description:SPDVDLGDISGINAS antigen name:Spike glycoprotein host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	17392374

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005028
landingPage:	http://www.iedb.org/assay/1418705

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2007

Dimension

study type:	b cell assays
subject species:	SARS coronavirus

Person

fullName:	Jincun Zhao Qianrong Huang Wei Wang Yan Zhang Ping Lv Xiao-Ming Gao

Data Type

method:	biological activity

Study

name:	Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus.
description:	Significant inhibition of SARS pseudovirus (where SARS spike protein is expressed in HIV-luciferase pseudotyped virus) infectivity of Vero cells is seen only in sera from mice immunized with fusion peptides that contain a T helper epitope derived from SARS nucleoprotein. In mice immunized with this peptide alone or with a mixture of this peptide and the T helper peptides, no response is seen. .

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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